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Research activities

Pegylation of Drugs and Proteins

RECENT PUBLICATIONS


  1. Grassi M., Bonora G.M., Drioli S., Cateni F., Zacchigan M., Pharmacokinetic analysis of multi PEG-theophylline conjugates, 2012, in press.
  2. Zacchigna M., Cateni F., Drioli S., Bonora G.M., Multifunctional high-molecular weight poly(ethylene glycol) Derivatives, Polymers, 2011, 3, 1076-1090
  3. Benedetti F., Berti F., Bonora G.M., Campaner P.; Drioli S., Synthesis and biological activity of new mixed HIV-PR inhibitors conjugated to bifunctional high-molecular weight poly(ethylene glycol), Letters in Organic Chemistry, 2011, 8(6), 380-384
  4. Gonelli A., Radillo O., Drioli S., Rimondi E., Secchiero P., Bonora G.M., , Pegylated TRAIL retains anti-leukemic cytotoxicity and exhibits improved signal transduction, Investigational New Drugs, 2010, DOI 10.1007/s10637-010-9599-8
  5. Rapozzi V., Zacchigna M., Biffi S., Garrovo C. , Cateni F., Stebel M , Zorzet S. , Bonora G.M. , Drioli S. and Xodo L. E., Conjugated PDT drug: Photosensitizing Activity and Tissue Distribution of PEGylated Pheophorbide a, Cancer Biol. Ther., 2010, 10(5), 1-12
  6. Veronese, F., Pasut, G.F., Drioli, S. and Bonora,GM, Poly(ethylene glycol)-protein, peptide and enzyme conjugates, in Macromolecular Anticancer Therapeutics, L.H. Reddy and P. Couvreur, Eds., Springer, New York, 2010, 265-291.
  7. Bonora G.M. and Drioli S., Reactive PEGs for Protein Conjugation, in PEGylated Protein Drugs: Basic Science and Clinical Applications, F.Veronese ed., Birkhause Verlag AG (CH), 2009, 33-45
  8. Zacchigna, M., Cateni, F., Grassi, M., Drioli, S., Bonora, G.M., New Multidrug (Dexamethasone and Theophylline) PEG-Conjugate: Synthesis, in vitro Release Studies and Intestinal Permeability, J. Drug Del. Sci.Tech., 2009, 19(3), 177-184
  9. Bonora, G.M. and Veronese, F., Engineering in a PTM: PEGylation, in Biopharmaceuticals: post-translational modifications, G. Walsh, Ed., Wiley, New York, Chapter 18, 2009, cap.14. 341-357
  10. Bonora, G.M and Drioli, S., Recent advances on patents in poly(ethylene glycol)-based drug delivery, Recent Patents on Drug Delivery and Formulation, 2008, 2, 189-195
  11. Zacchigna, M., Cateni, F. Di Luca, Voinovich, G., Perissutti, B., Drioli, S., Bonora, G.M., Synthesis of a new mPEG Dexamethasone Conjugate and preliminary bioavailability studies in rabbits, J. Drug Del. Sci.Tech., 2008, 18(3), 155-159
  12. Drioli, S., Bonora, G.M., Ballico, M., Synthesis and characterization of new multifunctional high-molecular weight PEG derivatives (MultiPEG)s, The Open Organic Chemistry Journal, 2008, 2, 17-25
  13. Bonora, G.M., Drioli, S., Ballico, M., Faccini, A.,Corradini, R., Cogoi, S. Xodo, L., PNA conjugated to high-molecular weight poly(ethylene glycol): synthesis and properties, Nucleosides, Nucleotides and Nucleic Acids, 2007, 26, 661-664
  14. Zacchigna, M. , Di Luca,G., Cateni F., Maurich V., Ballico M., Bonora, G.M, Drioli, S., New MultiPEG-conjugated theofilline derivatives; synthesis and pharmacological evaluations, European Journal of Pharmaceutical Sciences, 2007, 30, 343-350
  15. Campaner, P., Drioli, S., Bonora, G.M., Synthesis of Selectively End-Modified High-Molecular Weight Polyethyleneglycol, Letters in Organic Chemistry, 2006, 10, 773-779